Laboratory of Mammalian Cell Design and Engineering
Laboratory of Mammalian Cell Design and Engineering
Laboratory of Mammalian Cell Design and Engineering
Laboratory of Mammalian Cell Design and Engineering
Laboratory of Mammalian Cell Design and Engineering
GRADUATE STUDENTS
WELCOME TO THE MAMMALIAN CELL DESIGNERS' LAB
We study mammalian cell culture engineering for therapeutic protein production and develop valuable tools for mammalian synthetic biology. Particularly, we are interested in applying genome-scale science methodologies for reprogramming mammalian cell lines of interest into designer cell lines for multiple applications including i) therapeutic protein production, ii) diagnosis, and iii) drug discovery. Learn more
We are located at Department of Applied Chemistry and Biological Engineering and Department of Molecular Science and Technology in Ajou University, Korea.
PRINCIPLE INVESTIGATOR
Dr. Jae Seong Lee earned his B.S and Ph.D. in Biological Sciences from Korea Advanced Institute of Science and Technology (KAIST) and performed postdoctoral research in the Novo Nordisk Foundation Center for Biosustainability (CFB) at the Technical University of Denmark (DTU). His research has focused on the genetic and metabolic engineering of CHO cells for high level production of recombinant proteins. His current research interests are development of efficient mammalian genome editing technologies and rational design of mammalian cells. These efforts will be beneficial for patients and the society by greatly decreasing the therapeutic protein production costs. Ultimately, he would like to contribute to helping the Korean biopharma companies become key players in the competitive therapeutic protein market. Learn more
RECENT PUBLICATIONS
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"Implementation of Ubiquitous Chromatin Opening Elements as Artificial Integration Sites for CRISPR/Cas9-Mediated Knock-In in Mammalian Cells."
Kim SM, Lee J, Lee JS, Eng. Life Sci. (2023)
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"Limitations of the Plasmid-Based Cas9-Zinc Finger Fusion System for Homology-Directed Knock-In in Chinese Hamster Ovary Cells"
Kim D, Lee JS, Biotechnol. Bioproc. E. (2023)
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"Hybrid cell line development system utilizing site-specific integration and methotrexate-mediated gene amplification in Chinese hamster ovary cells"
Min H, Kim SM, Kim D, Lee S, Lee S, Lee JS, Front. Bioeng. Biotechnol. (2022)
Learn more
NEWS
MAR 2023
Jiwon joined our lab as a graduate student. WELCOME!
SEP 2022
Kyuhee joined our lab as a graduate student. WELCOME!
Jin Myeong won the Excellent Poster Award at KSBB Fall Meeting and International symposium (Jeju). Congratulation!
APR 2022
Sung Wook won the Excellent Poster Award at KSBB Spring Meeting and International symposium (Daejeon). Congratulation!
MAR 2022
Jaejin and Hyunjee join our lab as graduate students. WELCOME!
APR 2021
Seul Mi won the Excellent Poster Award at KSBB Spring Meeting and International symposium (Jeju). Congratulation!
MAR 2021
Jin Myeong, Honggi, and Sumin join our lab as graduate students. WELCOME!
JAN 2021
Dr. Lee gave an invited talk in PepTalk 2021 (Virtual event).
DEC 2020
Dr. Lee gave an invited talk in the 11th Bio-Pharma Tech Concert.
(http://biospectator.com/view/news_view.php?varAtcId=12094)
NOV 2020
Dr. Lee gave an invited talk in Division of Biological Science and Technology at Yonsei University (Wonju).
Dr. Lee gave an invited talk in Department of Pharmacology at Seoul National University of College of Medicine.
OCT 2020
Minji won the Excellent Poster Award at KSBB Fall Meeting and International symposium (Seoul). Congratulation!
SEP 2020
Dongwoo and Seul Mi join our lab as graduate students. WELCOME!
MAR 2020
Min Ho and Minji join our lab as graduate students. WELCOME!
OCT 2019
Dr. Lee gave an invited talk in KSBB Fall Meeting and International Symposium (Daegu).
Sung Wook won the Excellent Poster Award at KSBB Fall Meeting and International symposium. Congratulation!
MAY 2019
Dr. Lee gave a poster presentation in 26th Meeting of the European Society for Animal Cell Technology
(ESACT 2019) (Copenhagen, Denmark)
OCT 2018
Dr. Lee gave an invited talk in 2018 SNU Bioengineering Symposium (Seoul).
JUL 2018
Dr. Lee gave an invited talk in 2018 Antibody Society Korea Summer Workshop (Pyeongchang).
JUN 2018
Dr. Lee gave an invited talk in KMB 2018 Annual Meeting & International Symposium (Yeosu).
MAR 2018
Sung Wook and Youngsik join our lab as graduate students. WELCOME!
OCT 2017
Dr. Lee gave an invited talk in KSBB Fall Meeting and International Symposium (Busan).
SEP 2017
Dr. Lee joins Department of Molecular Science and Technology at Ajou University as an Assistant Professor.
UPCOMING EVENTS
Office: Paldal Hall 1006 (+82-31-219-3896)
Lab: Paldal Hall 827 (+82-31-219-2457)
Department of Molecular Science and Technology
Ajou University
206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea
Email: jaeseonglee@ajou.ac.kr