WELCOME TO THE MAMMALIAN CELL DESIGNERS' LAB

We study mammalian cell culture engineering for therapeutic protein production and develop valuable tools for mammalian synthetic biology. Particularly, we are interested in applying genome-scale science methodologies for reprogramming mammalian cell lines of interest into designer cell lines for multiple applications including i) therapeutic protein production, ii) diagnosis, and iii) drug discovery. Learn more 

 

We are located at Department of Applied Chemistry and Biological Engineering and Department of Molecular Science and Technology in Ajou University, Korea.

PRINCIPLE INVESTIGATOR

Dr. Jae Seong Lee earned his B.S and Ph.D. in Biological Sciences from Korea Advanced Institute of Science and Technology (KAIST) and performed postdoctoral research in the Novo Nordisk Foundation Center for Biosustainability (CFB) at the Technical University of Denmark (DTU). His research has focused on the genetic and metabolic engineering of CHO cells for high level production of recombinant proteins. His current research interests are development of efficient mammalian genome editing technologies and rational design of mammalian cells. These efforts will be beneficial for patients and the society by greatly decreasing the therapeutic protein production costs. Ultimately, he would like to contribute to helping the Korean biopharma companies become key players in the competitive therapeutic protein market. Learn more

RECENT PUBLICATIONS

  1. "A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes" 
    Karottki KJC et al., Metab. Eng. (2021) 
     

  2. “Controlling Ratios of Plasmid-Based Double Cut Donor and CRISPR/Cas9 Components to Enhance Targeted Integration of Transgenes in Chinese Hamster Ovary Cells”
    Shin SW*, Kim D*, Lee JS.
    Int. J. Mol. Sci. (2021)
     

  3. “Comprehensive Analysis of Genomic Safe Harbors as a Target Site for Stable Expression of Heterologous Gene in HEK293 Cells” 
    Kwak JM*, Lee Y*, Shin SW*, Lee JS. 
    New Biotechnol. (2021)

    Learn more

NEWS

MAR 2021

Jin Myeong, Honggi, and Sumin join our lab as graduate students. WELCOME!

JAN 2021

Dr. Lee gave an invited talk in PepTalk 2021 (Virtual event).

DEC 2020

Dr. Lee gave an invited talk in the 11th Bio-Pharma Tech Concert. 
(http://biospectator.com/view/news_view.php?varAtcId=12094)

NOV 2020

Dr. Lee gave an invited talk in Division of Biological Science and Technology at Yonsei University (Wonju).

Dr. Lee gave an invited talk in Department of Pharmacology at Seoul National University of College of Medicine.

OCT 2020

Minji won the Excellent Poster Award at KSBB Fall Meeting and International symposium. Congratulation!

SEP 2020

Dongwoo and Seul Mi join our lab as graduate students. WELCOME!

MAR 2020

Min Ho and Minji join our lab as graduate students. WELCOME!

OCT 2019

Dr. Lee gave an invited talk in KSBB Fall Meeting and International Symposium (Daegu).

Sung Wook won the Excellent Poster Award at KSBB Fall Meeting and International symposium. Congratulation!

MAY 2019
​Dr. Lee gave a poster presentation in 26th Meeting of the European Society for Animal Cell Technology
(ESACT 2019) (Copenhagen, Denmark)​

OCT 2018

Dr. Lee gave an invited talk in 2018 SNU Bioengineering Symposium (Seoul).

JUL 2018

Dr. Lee gave an invited talk in 2018 Antibody Society Korea Summer Workshop (Pyeongchang).

JUN 2018

Dr. Lee gave an invited talk in KMB 2018 Annual Meeting & International Symposium (Yeosu).


MAR 2018
Sung Wook and Youngsik join our lab as graduate students. WELCOME!


OCT 2017

Dr. Lee gave an invited talk in KSBB Fall Meeting and International Symposium (Busan).

SEP 2017

Dr. Lee joins Department of Molecular Science and Technology at Ajou University as an Assistant Professor.

UPCOMING EVENTS

Office: Paldal Hall 1006 (+82-31-219-3896)
Lab: Paldal Hall 827 (+82-31-219-2457)

Department of Molecular Science and Technology

Ajou University

206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea

Email: jaeseonglee@ajou.ac.kr

 Learn more

CONTACT