We study mammalian cell culture engineering for therapeutic protein production and develop valuable tools for mammalian synthetic biology. Particularly, we are interested in applying genome-scale science methodologies for reprogramming mammalian cell lines of interest into designer cell lines for multiple applications including i) therapeutic protein production, ii) diagnosis, and iii) drug discovery. Learn more 


We are located at Department of Applied Chemistry and Biological Engineering and Department of Molecular Science and Technology in Ajou University, Korea.


Dr. Jae Seong Lee earned his B.S and Ph.D. in Biological Sciences from Korea Advanced Institute of Science and Technology (KAIST) and performed postdoctoral research in the Novo Nordisk Foundation Center for Biosustainability (CFB) at the Technical University of Denmark (DTU). His research has focused on the genetic and metabolic engineering of CHO cells for high level production of recombinant proteins. His current research interests are development of efficient mammalian genome editing technologies and rational design of mammalian cells. These efforts will be beneficial for patients and the society by greatly decreasing the therapeutic protein production costs. Ultimately, he would like to contribute to helping the Korean biopharma companies become key players in the competitive therapeutic protein market. Learn more


  1. “Endogenous p21-Dependent Transgene Control for CHO Cell Engineering”
    Lee Y, Kwak JM, Lee JS.
    ACS Synth. Biol. (2020)

  2. “Comprehensive Analysis of Genomic Safe Harbors as a Target Site for Stable Expression of Heterologous Gene in HEK293 Cells” 
    Shin SH, Kim SH, Shin SW, Grav LM, Pedersen LE, Lee JS, Lee GM. 
    ACS Synth. Biol. (2020)

  3. “Optimized CRISPR/Cas9 Strategy for Homology-Directed Multiple Targeted Integration of Transgenes in CHO Cells”
    Shin SW, Lee JS. Biotechnol. Bioeng. (2020) 

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OCT 2019

Dr. Lee gave an invited talk in KSBB Fall Meeting and International Symposium (Daegu).

Sung Wook Shin won the Excellent Poster Award at KSBB Fall Meeting and International symposium. Congratulation!

MAY 2019
​Dr. Lee gave a poster presentation in 26th Meeting of the European Society for Animal Cell Technology
(ESACT 2019) (Copenhagen, Denmark)​

OCT 2018

Dr. Lee gave an invited talk in 2018 SNU Bioengineering Symposium (Seoul).

JUL 2018

Dr. Lee gave an invited talk in 2018 Antibody Society Korea Summer Workshop (Pyeongchang).

JUN 2018

Dr. Lee gave an invited talk in KMB 2018 Annual Meeting & International Symposium (Yeosu).

MAR 2018
Sung Wook and Young Sik join our lab as graduate students. WELCOME!

OCT 2017

Dr. Lee gave an invited talk in KSBB Fall Meeting and International Symposium (Busan).

SEP 2017

Dr. Lee joins Department of Molecular Science and Technology at Ajou University as an Assistant Professor.


Office: Paldal Hall 1006 (+82-31-219-3896)
Lab: Paldal Hall 832 (+82-31-219-2456)

Department of Molecular Science and Technology

Ajou University

206 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea

Email: jaeseonglee@ajou.ac.kr

 Learn more